GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2275426 | 1 | rs11810993 | chr1:46478793 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -6.43 | 3.87E-10 | Body mass index |
| BLCA | cis | rs12220777 | 1 | rs118110670 | chr10:81792242 | LOC219347 | chr10:81805991-81838949:- | 0.37 | 4.5 | 9.02E-6 | Chronic obstructive pulmonary disease-related biomarkers |
| BLCA | cis | rs2251844 | 1 | rs11856184 | chr15:43919162 | ADAL | chr15:43622872-43646094:+ | -0.39 | -4.43 | 1.23E-5 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs11856184 | chr15:43919162 | CATSPER2 | chr15:43922774-43959900:- | -0.36 | -5.27 | 2.33E-7 | Tumor biomarkers |
| BLCA | cis | rs78153629 | 1 | rs11858714 | chr15:40717447 | C15orf23 | chr15:40674922-40686488:+ | 0.35 | 5.67 | 2.83E-8 | Heschl's gyrus morphology |
| BLCA | cis | rs7224737 | 1 | rs11869069 | chr17:40287101 | DHX58 | chr17:40253422-40264751:- | -0.25 | -4.59 | 6.08E-6 | Fibrinogen levels |
| BLCA | cis | rs8072100 | 1 | rs11870935 | chr17:45732605 | C17orf57 | chr17:45401142-45518675:+ | -0.26 | -5.79 | 1.47E-8 | Very long-chain saturated fatty acid levels (fatty acid 20:0) |
| BLCA | cis | rs11622475 | 1 | rs1187446 | chr14:104409896 | TDRD9 | chr14:104394817-104519002:+ | 0.34 | 5.39 | 1.26E-7 | Bipolar disorder |
| BLCA | cis | rs11622475 | 1 | rs1187448 | chr14:104406627 | TDRD9 | chr14:104394817-104519002:+ | 0.35 | 5.54 | 5.49E-8 | Bipolar disorder |
| BLCA | cis | rs7246967 | 1 | rs11879853 | chr19:23029434 | ZNF492 | chr19:22817126-22850472:+ | 0.28 | 3.96 | 8.8E-5 | Bronchopulmonary dysplasia |
| BLCA | cis | rs4803480 | 1 | rs11882144 | chr19:42072602 | CEACAM21 | chr19:42055886-42093196:+ | 0.37 | 8.45 | 5.94E-16 | Schizophrenia |
| BLCA | cis | rs4803468 | 1 | rs11883104 | chr19:41923799 | B3GNT8 | chr19:41931265-41934635:- | -0.21 | -3.98 | 8.37E-5 | Height |
| BLCA | cis | rs7589728 | 1 | rs11893832 | chr2:88507537 | THNSL2 | chr2:88469835-88486145:+ | -0.55 | -5.5 | 7.08E-8 | Plasma clusterin levels |
| BLCA | cis | rs9309473 | 1 | rs11893881 | chr2:73824373 | ALMS1P | chr2:73872046-73912692:+ | 0.37 | 5.5 | 7.03E-8 | Metabolite levels |
| BLCA | cis | rs9309473 | 1 | rs11899740 | chr2:73631212 | ALMS1P | chr2:73872046-73912692:+ | 0.31 | 4.46 | 1.06E-5 | Metabolite levels |